Perma-Fix Environmental Services Inc PESI:NASDAQ

Verrica Pharmaceuticals (VRCA) shares slumped 24% after the US Food and Drug Administration declined to approve the company's new drug application for a skin infection treatment.

Edesa Biotech (EDSA) shares tumbled 21%, paring Monday's sharp rally on positive study data for COVID-19 therapy.

ZIVO Bioscience (ZIVO) shares fell 14%, paring Monday's surge.

Perma-Fix (PESI) shares decreased 11%. On Monday, the company said it won about $50 million in new contracts in Q3.

Discovery (DISCB) shares declined 10%, paring gains from the previous session.